If surgery is put off for older patients with hip fractures, there is a higher risk of morbidity and death. Avoid using conservative therapy until the risks of surgery outweigh the advantages. According to data, having hip surgery within 48 hours of admission improves the prognosis. Delaying the procedure increases the risk of mortality and pressure sores even while the glucose is not under control. Instead of postponing surgery, it is preferable to manage the hyperglycemia (for instance, with an intravenous insulin drip).
Erosive osteoarthritis (EOA) is indeed a subset of primary osteoarthritis (OA) that involves characteristic radiographic features. The diagnosis of erosive OA is primarily made based on the presence of central erosions and collapse of the subchondral bone in the affected joints. These radiographic findings help differentiate erosive OA from other forms of arthritis, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), which typically exhibit marginal erosions.
DDAVP, a vasopressin analog, can increase the ADH axis's activity and result in hyponatremia. Additionally, it has been demonstrated to promote endothelial cell release of von Willebrand factor. However, this medication might cause tachyphylaxis, and its effectiveness usually wears off after two or three consecutive doses. As a result, it cannot be administered again.
When von Willebrand factor attaches to glycoprotein 1, related to type IIB vWD, more platelets are cleared from the body. In individuals with type IIB vWD, DDAVP, which increases the release of von Willebrand factor, can result in thrombosis and severe thrombocytopenia and shouldn't be administered in this situation.
Clinical signs of vitamin B12 insufficiency in this patient include macrocytic anemia, neurological symptoms, a strict vegan diet, and borderline blood B12 levels. Methylmalonic acid and homocysteine levels can be checked in this situation to confirm the diagnosis. Due to their buildup in the setting of vitamin B12 insufficiency, both intermediates will grow. (In folate insufficiency, just homocysteine will be raised).
The next step would be to look for the cause of a vitamin B12 insufficiency diagnosis to be made and confirmed. The patient's strict vegan diet is the most likely cause in this case. Even while electromyography and nerve conduction testing would show that neuropathy existed, they would not give the required details to identify the cause. Similarly, if other causes are ruled out, a computed tomography (CT) of the lumbosacral spine can be necessary. However, there are better courses of action than this when enough clinical data points to a vitamin shortage.
The best way to define the patient's folate and vitamin B12 levels is borderline. Therefore, there are better courses of action than administering a therapeutic dose of vitamin B12 without first determining what is causing the neurological symptoms. A bone marrow analysis would not be required now because the peripheral blood smear and complete blood count showed no further related cellular abnormalities. The cause is more likely to be discovered by less invasive tests (such as serum metabolite intermediates).
Sinus bradycardia can occur as a pathogenic reaction in several illnesses, but it also happens in healthy people as an adaptive response, especially in well-conditioned individuals or during sleeping. Sinus bradycardia is a common and typical finding in healthy children and adults, especially during sleep when rates may briefly dip as low as 30 beats per minute and pauses of up to two seconds are not unusual. Sinoatrial (SA) node dysfunction, sick sinus syndrome, an abrupt myocardial infarction, obstructive sleep apnea, and infections may all present with sinus bradycardia as their initial symptoms. The patient was generally healthy, but the clinical history is consistent with a vasovagal near-syncope.
Pulmonary lymphangioleiomyomatosis (LAM) is a rare lung disease characterized pathologically by cyst formation and multifocal, nodular proliferation of immature smooth muscle and perivascular epithelioid cells (LAM cells). High-resolution CT scans show characteristic diffuse thin-walled cysts. In a relatively young female non-smoker of child-bearing age, this is the most likely diagnosis. Most patients are symptomatic at presentation, with dyspnea being the most common complaint. Complications include pneumothorax, hemoptysis, chylothorax, chyloperitoneum, chylopericardium, and development of lymphangioleiomyomas of the lymph vessels.
The intermittent symptoms of this patient are most consistent with upper respiratory obstruction. The diagnosis most likely to be made is paradoxical vocal cord movements. Due to improper adduction of the vocal cords during inspiration in patients with paradoxical vocal cord motion, stridor, and respiratory discomfort ensue.
One sign of this potential diagnosis is a history of repeated visits to the ED for respiratory distress without any other obvious explanation. Exercise, among other things, can cause the symptoms to appear, and they usually go away independently. Although spirometry will show normal expiration and perhaps aberrant inspiratory function, it may be mistaken for asthma. The preferred diagnostic technique is laryngoscopy, which makes it possible to see the unusual cord movement in real-time.
