The American Civil War, which began in 1861, was primarily caused by disagreements over the issues of states' rights and the institution of slavery.
The Lewis and Clark Expedition, which began in 1804, was aimed at exploring and mapping the newly acquired Louisiana Territory and finding a water route to the Pacific Ocean.
The Monroe Doctrine, articulated in 1823, was aimed at preventing European powers from colonizing or interfering in the affairs of the Western Hemisphere.
The Boston Tea Party in 1773 was a significant event that heightened tensions between the American colonies and Britain, leading to the outbreak of the American Revolutionary War in 1775.
The 13th Amendment, ratified in 1865, abolished slavery in the United States, marking a significant step in the struggle for civil rights and equality.