A patient receiving chemotherapy develops a wound that fails to progress through the proliferative phase. Chemotherapy most likely impairs healing by:
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A
Increasing platelet-derived growth factor (PDGF) to toxic levels
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B
Suppressing rapidly dividing cells including fibroblasts and keratinocytes
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C
Causing direct collagenase release from tumor cells
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D
Elevating serum calcium, which inhibits angiogenesis