A patient with acute ischemic stroke is on a direct oral anticoagulant (DOAC). When can IV tPA be safely administered?
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A
Any time if the last DOAC dose was > 12 hours ago
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B
Only if specific reversal agent was administered and coagulation assays are normal
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C
Immediately if clinical need is high
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D
Never; DOACs are an absolute contraindication regardless of timing