ABT Study Guide 2026
Everything you need to pass the ABT exam in one place: the exam format, every topic to study, real practice questions with explanations, flashcards, and full-length practice tests. Free, no sign-up needed.
📚 ABT Topics to Study (22)
✍️ Sample ABT Questions & Answers
1. Endocrine-disrupting chemicals (EDCs) can mimic or block hormones. Which effect describes a chemical that binds estrogen receptors without activating them?
An estrogen receptor antagonist binds to estrogen receptors but does not activate transcription, effectively blocking endogenous estrogen from exerting its effects.
2. Which mathematical model best describes the kinetics of ethanol elimination from the blood at typical intoxicating concentrations?
At intoxicating ethanol concentrations, liver alcohol dehydrogenase (ADH) is saturated, and ethanol is eliminated at a constant rate (~0.015–0.020 g/dL/hr) independent of concentration — zero-order kinetics.
3. Lead exposure in children is most commonly associated with which source in older US homes?
Lead-based paint used in homes built before 1978 is the most common source of lead exposure in US children through ingestion of paint chips and inhalation of dust.
4. The area under the concentration-time curve (AUC) is directly proportional to which pharmacokinetic parameter?
AUC = F × Dose / CL; for a given dose and bioavailability, AUC is inversely proportional to clearance and directly represents total systemic exposure.
5. Methylmercury exposure in humans primarily occurs through:
Methylmercury bioaccumulates in fish and seafood, making dietary consumption of large predatory fish (tuna, swordfish) the primary human exposure route.
6. The presence of which compound in improperly stored potatoes can cause gastrointestinal and neurological disorders?
Solanine is a glycoalkaloid toxin naturally present in potatoes, especially in green parts, sprouts, and eyes, or in potatoes that have been improperly stored and exposed to light. Ingesting high levels of solanine can cause a range of symptoms, from gastrointestinal upset like nausea and vomiting to neurological disorders such as headaches and hallucinations. It's crucial to avoid consuming green or sprouting potatoes.