ABT Forensic Toxicology 3

Question 1

Fentanyl analogs such as carfentanil are classified as Schedule I substances and are most commonly detected in forensic cases involving:

Accepted Answer

Opioid overdose deaths with no prescribed opioid use

Answer

Alcohol-related traffic fatalities

Answer

Stimulant-related cardiac events

Answer

Drug-facilitated sexual assault

Question 2

Which principle explains why oral fluid (saliva) drug testing reflects recent drug use more accurately than urine?

Accepted Answer

Oral fluid primarily contains parent drug reflecting recent blood levels

Answer

Saliva contains higher concentrations of phase II metabolites

Answer

Saliva has slower elimination kinetics than urine

Answer

Oral fluid pH enhances drug stability over time

Question 3

A critical difference between therapeutic drug monitoring (TDM) and forensic toxicology is that forensic toxicology:

Accepted Answer

Must maintain legally defensible chain of custody and documentation

Answer

Uses less sensitive analytical methods

Answer

Only tests for a single drug class at a time

Answer

Does not require confirmatory testing

Question 4

Which compound is measured in blood as a biomarker for chronic heavy alcohol use and has a detection window of approximately 2–4 weeks?

Accepted Answer

Phosphatidylethanol (PEth)

Answer

Ethyl glucuronide (EtG)

Answer

Gamma-glutamyl transferase (GGT)

Answer

Carbohydrate-deficient transferrin (CDT)

Question 5

In forensic death investigations, which toxicological finding is most useful for estimating postmortem interval (PMI)?

Accepted Answer

Vitreous potassium levels

Answer

Blood alcohol concentration

Answer

Liver drug concentrations

Answer

Urine creatinine levels

Question 6

Which analytical technique is most commonly used in modern forensic toxicology laboratories for multi-drug screening in a single run?

Accepted Answer

Liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Answer

Enzyme-multiplied immunoassay technique (EMIT)

Answer

Infrared spectroscopy (IR)

Answer

Colorimetric spot tests