ABT Occupational Toxicology 2

Question 1

Silicosis results from occupational inhalation of which form of silica?

Accepted Answer

Crystalline silica (quartz)

Answer

Amorphous silica (diatomaceous earth)

Answer

Silicon carbide

Answer

Vitreous fused silica

Question 2

Which type of asbestos fiber is associated with the greatest risk of mesothelioma due to its biopersistent, thin, needle-like morphology?

Accepted Answer

Crocidolite (blue asbestos)

Answer

Chrysotile (white asbestos)

Answer

Amosite (brown asbestos)

Answer

Tremolite

Question 3

Occupational asthma caused by toluene diisocyanate (TDI) primarily involves which immunological mechanism?

Accepted Answer

IgE-mediated (Type I) hypersensitivity

Answer

IgG-mediated (Type III) immune complex deposition

Answer

Cell-mediated (Type IV) delayed hypersensitivity

Answer

Direct pharmacological airway irritation without sensitization

Question 4

n-Hexane causes peripheral neuropathy through which specific mechanism?

Accepted Answer

Formation of 2,5-hexanedione which cross-links neurofilament proteins

Answer

Direct membrane disruption by the parent compound

Answer

Inhibition of axonal acetylcholinesterase activity

Answer

Competitive inhibition of myelin synthesis

Question 5

Minamata disease is caused by occupational and environmental exposure to which toxic substance?

Accepted Answer

Methylmercury

Answer

Inorganic lead

Answer

Cadmium

Answer

Inorganic arsenic

Question 6

Coal workers' pneumoconiosis (black lung disease) is caused by chronic inhalation of which dust?

Accepted Answer

Coal dust

Answer

Crystalline silica dust

Answer

Talc particles

Answer

Iron oxide fumes

Question 7

The General Duty Clause (Section 5(a)(1)) of the OSH Act requires employers to:

Accepted Answer

Provide a workplace free from recognized hazards likely to cause death or serious harm

Answer

Post all OSHA regulations visibly in the workplace

Answer

Conduct annual certified industrial hygiene surveys

Answer

Register all hazardous chemicals with OSHA before use