Practice Test GeeksABT - American Board of Toxicology Practice Test
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Clinical Toxicology Flashcards

6 cards from real ABT practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Which antidote is used to treat acetaminophen overdose by replenishing glutathione stores?

    Answer: N-acetylcysteine

    N-acetylcysteine (NAC) is the standard antidote for acetaminophen overdose, acting as a glutathione precursor to prevent hepatotoxicity.

  2. The Rumack-Matthew nomogram is used to assess overdose risk from which substance?

    Answer: Acetaminophen

    The Rumack-Matthew nomogram plots serum acetaminophen concentration against time post-ingestion to predict hepatotoxicity risk.

  3. Which toxidrome is characterized by miosis, bradycardia, excessive secretions, and bronchospasm?

    Answer: Cholinergic

    The cholinergic toxidrome results from excess acetylcholine activity and is remembered by the mnemonic SLUDGE (Salivation, Lacrimation, Urination, Defecation, GI distress, Emesis).

  4. Which specific antidote reverses benzodiazepine-induced CNS and respiratory depression?

    Answer: Flumazenil

    Flumazenil is a competitive benzodiazepine receptor antagonist used to reverse benzodiazepine sedation and respiratory depression.

  5. A patient presents with altered mental status, metabolic acidosis, and an elevated osmol gap. Which toxin is most likely responsible?

    Answer: Ethylene glycol

    Ethylene glycol ingestion causes an elevated osmol gap early and an elevated anion gap metabolic acidosis as it is metabolized to oxalic acid.

  6. Digoxin toxicity is potentiated by which electrolyte abnormality?

    Answer: Hypokalemia

    Hypokalemia increases digoxin toxicity because potassium and digoxin compete for the same binding site on the Na+/K+-ATPase pump.