ABPath Hematopathology 2

Question 1

Auer rods on a peripheral blood smear are most characteristic of which condition?

Accepted Answer

Acute myeloid leukemia

Answer

Auer rods are azurophilic cytoplasmic inclusions of fused primary granules seen in myeloblasts of AML.

Question 2

The t(9;22) BCR-ABL1 fusion is the defining genetic lesion of which chronic myeloproliferative neoplasm?

Accepted Answer

Chronic myeloid leukemia

Answer

The Philadelphia chromosome t(9;22) producing BCR-ABL1 defines CML.

Question 3

A CD5-positive, CD23-positive small B-cell lymphoma with smudge cells on smear is most consistent with:

Accepted Answer

Chronic lymphocytic leukemia/small lymphocytic lymphoma

Answer

CLL/SLL is CD5+/CD23+ and classically shows smudge cells on the peripheral smear.

Question 4

Reed-Sternberg cells are the diagnostic hallmark of which lymphoma?

Accepted Answer

Classic Hodgkin lymphoma

Answer

Binucleate Reed-Sternberg cells (CD15+/CD30+) define classic Hodgkin lymphoma.

Question 5

Which stain is used to demonstrate iron stores in bone marrow aspirate smears?

Accepted Answer

Prussian blue (Perls)

Answer

Prussian blue (Perls) reaction highlights hemosiderin iron in marrow.

American Board of Pathology (ABPath) Practice Test