ABPath Neuropathology

Question 1

Which histologic feature is MOST characteristic of glioblastoma multiforme (GBM)?

Accepted Answer

Pseudopalisading necrosis

Answer

Rosenthal fibers

Answer

Homer Wright rosettes

Answer

Verocay bodies

Question 2

A 10-year-old presents with a cerebellar mass; biopsy shows a biphasic pattern with compact Rosenthal fiber-rich areas and loose microcystic areas. What is the most likely diagnosis?

Accepted Answer

Pilocytic astrocytoma

Answer

Medulloblastoma

Answer

Ependymoma

Answer

Diffuse intrinsic pontine glioma

Question 3

Which immunohistochemical marker is MOST useful for distinguishing meningioma from other CNS tumors?

Accepted Answer

EMA

Answer

GFAP

Answer

Synaptophysin

Answer

S-100

Question 4

Lewy bodies, the pathologic hallmark of Parkinson disease, are composed primarily of which protein?

Accepted Answer

Alpha-synuclein

Answer

Tau

Answer

TDP-43

Answer

Amyloid beta

Question 5

Which variant of medulloblastoma carries the BEST prognosis according to WHO 2021 classification?

Accepted Answer

WNT-activated

Answer

Large cell/anaplastic

Answer

Classic

Answer

Desmoplastic/nodular

Question 6

Neurofibrillary tangles seen in Alzheimer disease are composed primarily of which protein?

Accepted Answer

Hyperphosphorylated tau

Answer

Alpha-synuclein

Answer

Prion protein

Answer

Ubiquitin