ABPath Hematopathology 2

Question 1

Auer rods on a peripheral blood smear are most characteristic of which condition?

Accepted Answer

Acute myeloid leukemia

Answer

Chronic lymphocytic leukemia

Answer

Hairy cell leukemia

Answer

Multiple myeloma

Question 2

The t(9;22) BCR-ABL1 fusion is the defining genetic lesion of which chronic myeloproliferative neoplasm?

Accepted Answer

Chronic myeloid leukemia

Answer

Polycythemia vera

Answer

Essential thrombocythemia

Answer

Primary myelofibrosis

Question 3

A CD5-positive, CD23-positive small B-cell lymphoma with smudge cells on smear is most consistent with:

Accepted Answer

Chronic lymphocytic leukemia/small lymphocytic lymphoma

Answer

Mantle cell lymphoma

Answer

Follicular lymphoma

Answer

Burkitt lymphoma

Question 4

Reed-Sternberg cells are the diagnostic hallmark of which lymphoma?

Accepted Answer

Classic Hodgkin lymphoma

Answer

Diffuse large B-cell lymphoma

Answer

Marginal zone lymphoma

Answer

Anaplastic large cell lymphoma

Question 5

Which stain is used to demonstrate iron stores in bone marrow aspirate smears?

Accepted Answer

Prussian blue (Perls)

Answer

Periodic acid-Schiff

Answer

Myeloperoxidase

Answer

Reticulin silver stain

Question 6

The JAK2 V617F mutation is most frequently associated with which myeloproliferative neoplasm?

Accepted Answer

Polycythemia vera

Answer

Chronic myeloid leukemia

Answer

Acute promyelocytic leukemia

Answer

Chronic lymphocytic leukemia

Question 7

A serum protein electrophoresis showing a monoclonal M-spike with marrow plasmacytosis and lytic bone lesions indicates:

Accepted Answer

Multiple myeloma

Answer

Waldenstrom macroglobulinemia

Answer

Reactive plasmacytosis

Answer

Monoclonal gammopathy of undetermined significance