ABPath Gastrointestinal Pathology

Question 1

Barrett esophagus is defined histologically by the presence of which type of metaplasia?

Accepted Answer

Intestinal metaplasia with goblet cells

Answer

Gastric fundic metaplasia

Answer

Squamous metaplasia

Answer

Pseudostratified columnar metaplasia

Question 2

Helicobacter pylori preferentially colonizes which region of the stomach?

Accepted Answer

Antrum

Answer

Fundus

Answer

Cardia

Answer

Greater curvature body

Question 3

Which histologic feature BEST distinguishes Crohn disease from ulcerative colitis?

Accepted Answer

Transmural inflammation with granulomas

Answer

Crypt abscesses

Answer

Goblet cell depletion

Answer

Mucosal ulceration

Question 4

Hirschsprung disease results from absence of ganglion cells in which layer of the bowel wall?

Accepted Answer

Submucosal (Meissner) and myenteric (Auerbach) plexuses

Answer

Muscularis mucosae

Answer

Lamina propria

Answer

Serosa

Question 5

A villous adenoma of the rectum is associated with highest risk for malignant transformation compared to other polyp types because it has:

Accepted Answer

Largest surface area with maximal dysplasia exposure

Answer

Highest density of goblet cells

Answer

Submucosal invasion at presentation

Answer

Microsatellite instability

Question 6

Lynch syndrome (hereditary non-polyposis colorectal cancer) is caused by germline mutations in which genes?

Accepted Answer

MLH1, MSH2, MSH6, PMS2 (MMR genes)

Answer

APC and MUTYH

Answer

BRCA1 and BRCA2

Answer

SMAD4 and BMPR1A