ABPath General Pathology Principles 3

Question 1

The predominant cell type in acute inflammation during the first 24 hours is the:

Accepted Answer

Neutrophil

Answer

Neutrophils are the first responders and dominate the early acute inflammatory infiltrate.

Question 2

Which vascular change is responsible for the redness and warmth (rubor and calor) of acute inflammation?

Accepted Answer

Vasodilation and increased blood flow

Answer

Vasodilation increases local blood flow, producing the warmth and redness of inflammation.

Question 3

Granulomatous inflammation is characterized by aggregates of activated macrophages known as:

Accepted Answer

Epithelioid cells

Answer

Granulomas contain epithelioid histiocytes, which are activated macrophages with abundant cytoplasm.

Question 4

The chemical mediator most responsible for pain in inflammation, along with prostaglandins, is:

Accepted Answer

Bradykinin

Answer

Bradykinin and prostaglandins are key mediators that sensitize nerve endings and produce pain.

Question 5

Leukocyte rolling along the endothelium during inflammation is mediated primarily by:

Accepted Answer

Selectins

Answer

Selectins mediate the initial loose, rolling adhesion of leukocytes to activated endothelium.

American Board of Pathology (ABPath) Practice Test