ABPath Blood Banking and Transfusion 2

Question 1

A patient's serum reacts with all reagent red cells in an antibody panel including the autocontrol. What is the most likely cause?

Accepted Answer

A warm autoantibody

Answer

Pan-reactivity with a positive autocontrol typically indicates a warm autoantibody.

Question 2

Which blood group system antigen is destroyed by treating red cells with proteolytic enzymes like ficin?

Accepted Answer

Fya (Duffy)

Answer

Duffy antigens (Fya/Fyb) are denatured by proteolytic enzymes such as ficin and papain.

Question 3

A group O mother delivers a group A infant with a positive DAT and jaundice at birth. What is the most likely diagnosis?

Accepted Answer

ABO hemolytic disease of the newborn

Answer

Group O mothers produce IgG anti-A,B that crosses the placenta causing ABO HDN.

Question 4

What is the minimum hemoglobin concentration typically required for an allogeneic whole blood donor in the US?

Accepted Answer

12.5 g/dL

Answer

US regulations require a minimum hemoglobin of 12.5 g/dL for allogeneic donors.

Question 5

A febrile nonhemolytic transfusion reaction is most commonly caused by which mechanism?

Accepted Answer

Cytokines from donor leukocytes and recipient antibodies to leukocytes

Answer

FNHTRs result from accumulated cytokines and recipient anti-leukocyte antibodies.

American Board of Pathology (ABPath) Practice Test