DVM Clinical Pathology and Diagnostics 5

Question 1

A dog has a prolonged APTT with a normal PT. Which coagulation factor deficiency is most consistent with this pattern?

Accepted Answer

Factor VIII deficiency (hemophilia A)

Answer

Factor VIII is part of the intrinsic pathway (measured by APTT only), so its deficiency prolongs APTT while PT remains normal.

Question 2

A dog's serum biochemistry shows a markedly elevated GGT with mild ALT elevation. Which condition is most associated with this pattern in dogs?

Accepted Answer

Biliary disease or cholestasis

Answer

GGT is a sensitive marker of cholestasis and biliary disease in dogs; marked elevation with modest ALT suggests primary biliary rather than hepatocellular pathology.

Question 3

A feline tracheal wash yields a smear with many eosinophils and Curschmann's spirals. What condition does this suggest?

Accepted Answer

Feline asthma (allergic bronchitis)

Answer

Eosinophilic airway inflammation with Curschmann's spirals (mucus plugs from small airways) is characteristic of feline allergic bronchitis (asthma).

Question 4

On urinalysis of a dog with suspected diabetes mellitus, which combination of findings is most expected?

Accepted Answer

USG 1.050, glucosuria, ketonuria, proteinuria

Answer

Uncontrolled diabetes mellitus causes glucosuria and, in ketoacidosis, ketonuria; USG is often high due to glucosuria acting as an osmotic agent.

Question 5

A dog has a serum calcium of 14.5 mg/dL and a PTH-rP level that is markedly elevated. What is the most likely diagnosis?

Accepted Answer

Humoral hypercalcemia of malignancy

Answer

PTH-related protein (PTH-rP) is secreted by neoplasms (commonly anal sac apocrine gland adenocarcinoma and lymphoma) and is the leading cause of humoral hypercalcemia of malignancy.

DVM - Doctor of Veterinary Medicine Practice Test

DVM - Doctor of Veterinary Medicine Practice Test

DVM Clinical Pathology and Diagnostics 5