DVM Clinical Pathology and Diagnostics 2

Question 1

A dog presents with a PCV of 18% and marked spherocytosis on blood smear. Which Coombs test result would confirm immune-mediated hemolytic anemia?

Accepted Answer

Positive direct Coombs

Answer

A positive direct Coombs test detects antibodies or complement bound to the surface of red blood cells, confirming IMHA.

Question 2

A cat's urinalysis shows a USG of 1.008 with concurrent azotemia. How should this finding be interpreted?

Accepted Answer

Renal azotemia with inadequate concentrating ability

Answer

A USG of 1.008 (isosthenuria) with azotemia indicates the kidneys cannot concentrate urine, pointing to primary renal disease.

Question 3

Which bone marrow finding is most consistent with a diagnosis of aplastic anemia in a dog?

Accepted Answer

Hypocellular marrow with fat cell replacement

Answer

Aplastic anemia is characterized by hypocellular marrow where hematopoietic cells are replaced by fat cells, causing pancytopenia.

Question 4

A horse has serum chemistry showing total bilirubin of 8 mg/dL with direct bilirubin of 0.4 mg/dL. What is the most likely cause?

Accepted Answer

Fasting hyperbilirubinemia

Answer

Horses commonly develop fasting-induced hyperbilirubinemia due to decreased hepatic uptake of unconjugated bilirubin, with predominantly indirect fraction elevated.

Question 5

On cytology of a lymph node aspirate, you observe a monomorphic population of large lymphocytes with prominent nucleoli comprising >80% of cells. What is the most likely diagnosis?

Accepted Answer

Lymphoma

Answer

A monomorphic population of large, atypical lymphocytes exceeding 80% of the cell population is highly indicative of lymphoma.

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DVM - Doctor of Veterinary Medicine Practice Test

DVM Clinical Pathology and Diagnostics 2