AOCNP Cancer Pharmacology and Chemotherapy 3

Question 1

Which antiemetic class is the MOST effective for preventing acute chemotherapy-induced nausea and vomiting (CINV) from highly emetogenic regimens?

Accepted Answer

5-HT3 receptor antagonists combined with NK1 antagonists and dexamethasone

Answer

Triple antiemetic prophylaxis with a 5-HT3 antagonist, NK1 antagonist (aprepitant), and dexamethasone is the guideline-recommended standard for highly emetogenic chemotherapy.

Question 2

Cisplatin nephrotoxicity is best prevented by:

Accepted Answer

Aggressive pre- and post-hydration with normal saline

Answer

High-volume saline hydration before, during, and after cisplatin maintains high urine flow and dilutes the platinum in renal tubules, preventing acute kidney injury.

Question 3

Capecitabine (Xeloda) is an oral prodrug of which chemotherapy agent?

Accepted Answer

5-Fluorouracil (5-FU)

Answer

Capecitabine is enzymatically converted to 5-FU preferentially in tumor cells, allowing oral delivery with tumor-targeted activation.

Question 4

Which biologic agent works by depleting CD20-positive B cells and is used in certain lymphomas?

Accepted Answer

Rituximab

Answer

Rituximab is a chimeric anti-CD20 monoclonal antibody that depletes CD20-expressing B cells through ADCC, CDC, and direct apoptosis induction.

Question 5

The dose-limiting toxicity of vincristine is:

Accepted Answer

Peripheral neurotoxicity

Answer

Vincristine causes progressive sensory and motor peripheral neuropathy by binding tubulin and disrupting axonal transport in nerve cells.

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP Cancer Pharmacology and Chemotherapy 3