AOCNP Cancer Pharmacology and Chemotherapy 3

Question 1

Which antiemetic class is the MOST effective for preventing acute chemotherapy-induced nausea and vomiting (CINV) from highly emetogenic regimens?

Accepted Answer

5-HT3 receptor antagonists combined with NK1 antagonists and dexamethasone

Answer

Prochlorperazine alone

Answer

Lorazepam alone

Answer

Metoclopramide as monotherapy

Question 2

Cisplatin nephrotoxicity is best prevented by:

Accepted Answer

Aggressive pre- and post-hydration with normal saline

Answer

Dose reduction only

Answer

Concurrent diuretic use alone

Answer

Switching to carboplatin without hydration

Question 3

Capecitabine (Xeloda) is an oral prodrug of which chemotherapy agent?

Accepted Answer

5-Fluorouracil (5-FU)

Answer

Gemcitabine

Answer

Cytarabine

Answer

Methotrexate

Question 4

Which biologic agent works by depleting CD20-positive B cells and is used in certain lymphomas?

Accepted Answer

Rituximab

Answer

Cetuximab

Answer

Ramucirumab

Answer

Denosumab

Question 5

The dose-limiting toxicity of vincristine is:

Accepted Answer

Peripheral neurotoxicity

Answer

Myelosuppression

Answer

Nephrotoxicity

Answer

Cardiotoxicity

Question 6

G-CSF (filgrastim) is primarily used in oncology to:

Accepted Answer

Stimulate neutrophil production to reduce the duration of neutropenia

Answer

Prevent thrombocytopenia after chemotherapy

Answer

Treat anemia in cancer patients

Answer

Block chemotherapy-induced alopecia