AOCNP Hematologic Malignancies

Question 1

Which type of leukemia is the most common leukemia in adults in the United States?

Accepted Answer

Chronic lymphocytic leukemia (CLL)

Answer

Acute lymphoblastic leukemia (ALL)

Answer

Acute myeloid leukemia (AML)

Answer

Chronic myeloid leukemia (CML)

Question 2

The Philadelphia chromosome, resulting from a t(9;22) translocation that produces the BCR-ABL fusion gene, is the hallmark of which leukemia?

Accepted Answer

Chronic myeloid leukemia (CML)

Answer

Acute myeloid leukemia (AML)

Answer

Chronic lymphocytic leukemia (CLL)

Answer

Hairy cell leukemia

Question 3

A patient is diagnosed with acute promyelocytic leukemia (APL, AML-M3). Which agent is a cornerstone of induction therapy that induces differentiation of malignant promyelocytes?

Accepted Answer

All-trans retinoic acid (ATRA)

Answer

Cytarabine (ara-C)

Answer

Daunorubicin

Answer

Hydroxyurea

Question 4

A patient with newly diagnosed AML has a FLT3-ITD mutation. What is the clinical significance of this finding?

Accepted Answer

It is associated with poor prognosis and warrants addition of a FLT3 inhibitor such as midostaurin

Answer

It confers a favorable prognosis and no additional targeted therapy is needed

Answer

It indicates the patient has APL and should receive ATRA

Answer

It predicts complete remission with standard chemotherapy alone

Question 5

Which of the following is the most accurate description of a complete cytogenetic response (CCyR) to imatinib therapy in CML?

Accepted Answer

No Philadelphia chromosome-positive cells detected in cytogenetic analysis (0% Ph+ metaphases)

Answer

BCR-ABL transcript undetectable by PCR

Answer

White blood cell count normalized to within normal limits

Answer

Fewer than 35% Philadelphia chromosome-positive metaphases

Question 6

The Rai and Binet staging systems are used to classify the prognosis of which hematologic malignancy?

Accepted Answer

Chronic lymphocytic leukemia (CLL)

Answer

Chronic myeloid leukemia (CML)

Answer

Hodgkin lymphoma

Answer

Multiple myeloma

Question 7

Tumor lysis syndrome (TLS) is most likely to occur following the initiation of treatment in which clinical scenario?

Accepted Answer

A patient with high-grade Burkitt lymphoma beginning chemotherapy

Answer

A patient with low-grade follicular lymphoma starting rituximab maintenance

Answer

A patient with CML beginning imatinib in chronic phase

Answer

A patient with multiple myeloma starting lenalidomide