AOCNP Cancer Pharmacology and Chemotherapy

Question 1

Which class of chemotherapy agents acts by cross-linking DNA strands to prevent replication?

Accepted Answer

Alkylating agents

Answer

Antimetabolites

Answer

Vinca alkaloids

Answer

Topoisomerase inhibitors

Question 2

Cardiotoxicity is the major dose-limiting toxicity associated with which chemotherapy class?

Accepted Answer

Anthracyclines

Answer

Taxanes

Answer

Platinum compounds

Answer

Alkylating agents

Question 3

The mechanism of action of methotrexate is:

Accepted Answer

Inhibition of dihydrofolate reductase, depleting folate required for DNA synthesis

Answer

Intercalation between DNA base pairs

Answer

Binding to tubulin to prevent spindle formation

Answer

Inhibition of topoisomerase II

Question 4

Which taxane is approved for albumin-bound nanoparticle formulation to reduce hypersensitivity and improve delivery?

Accepted Answer

Nab-paclitaxel (Abraxane)

Answer

Docetaxel

Answer

Cabazitaxel

Answer

Ixabepilone

Question 5

Peripheral neuropathy is the primary dose-limiting toxicity of which agent?

Accepted Answer

Oxaliplatin

Answer

Gemcitabine

Answer

Irinotecan

Answer

Bleomycin

Question 6

Irinotecan causes severe delayed diarrhea through which mechanism?

Accepted Answer

Active SN-38 metabolite inhibiting topoisomerase I in intestinal epithelium

Answer

Direct mucosal alkylation

Answer

Serotonin release in the gut

Answer

Antimetabolite interference with enterocyte folate metabolism