AOCNP Cancer Screening and Prevention

Question 1

At what age does the USPSTF recommend initiating annual low-dose CT (LDCT) screening for lung cancer in high-risk individuals?

Accepted Answer

50 years

Answer

45 years

Answer

55 years

Answer

60 years

Question 2

The HPV vaccine is most effective when administered:

Accepted Answer

Before sexual debut, ideally at age 11–12

Answer

After first sexual exposure

Answer

Only to females younger than 18

Answer

At any age up to 50 without preference

Question 3

Which stool-based test detects blood AND altered DNA markers from colorectal neoplasms?

Accepted Answer

Cologuard (stool DNA test, sDNA-FIT)

Answer

Guaiac fecal occult blood test (gFOBT)

Answer

Fecal immunochemical test (FIT) alone

Answer

Carcinoembryonic antigen (CEA) blood test

Question 4

The BRCA1/2 mutation confers the highest lifetime risk for which two cancers?

Accepted Answer

Breast and ovarian cancer

Answer

Breast and colon cancer

Answer

Ovarian and pancreatic cancer

Answer

Breast and lung cancer

Question 5

Lynch syndrome increases lifetime risk of which cancer most significantly?

Accepted Answer

Colorectal cancer

Answer

Breast cancer

Answer

Lung cancer

Answer

Prostate cancer

Question 6

Chemoprevention with tamoxifen is recommended for which group of high-risk women?

Accepted Answer

Women age 35+ with ≥1.7% 5-year breast cancer risk (Gail model) who are premenopausal

Answer

All women over 50 as routine prevention

Answer

Women with BRCA2 mutation as sole treatment

Answer

Women with active ER-negative breast cancer