ABPath Pathology 5

Question 1

Which oncogene is most classically amplified in HER2-positive breast carcinoma and targeted by trastuzumab?

Accepted Answer

ERBB2 (HER2/neu)

Answer

ERBB2 (HER2/neu) amplification defines HER2-positive breast cancer treated with trastuzumab.

Question 2

Which pattern of cell death is characterized by activation of caspases, cell shrinkage, and no surrounding inflammation?

Accepted Answer

Apoptosis

Answer

Apoptosis is programmed, caspase-mediated death without inflammatory response.

Question 3

Depositions of monosodium urate crystals with negative birefringence are diagnostic of?

Accepted Answer

Gout

Answer

Needle-shaped, negatively birefringent monosodium urate crystals confirm gout.

Question 4

Which cell type predominates in a chronic inflammatory infiltrate along with lymphocytes and plasma cells?

Accepted Answer

Macrophages

Answer

Macrophages, lymphocytes, and plasma cells characterize chronic inflammation.

Question 5

Orphan Annie eye nuclei and nuclear grooves are cytologic features of which thyroid malignancy?

Accepted Answer

Papillary thyroid carcinoma

Answer

Empty-appearing 'Orphan Annie' nuclei and grooves are diagnostic of papillary thyroid carcinoma.

American Board of Pathology (ABPath) Practice Test