ABPath Pathology 4

Question 1

Which glomerular disease shows a 'wire-loop' appearance and is strongly associated with systemic lupus erythematosus?

Accepted Answer

Diffuse proliferative glomerulonephritis

Answer

Wire-loop lesions from subendothelial immune deposits characterize lupus diffuse proliferative GN.

Question 2

Ferruginous bodies (asbestos bodies) in lung tissue indicate prior exposure to?

Accepted Answer

Asbestos

Answer

Iron-coated asbestos fibers form dumbbell-shaped ferruginous bodies.

Question 3

Which tumor marker is most useful for monitoring hepatocellular carcinoma and certain germ-cell tumors?

Accepted Answer

Alpha-fetoprotein (AFP)

Answer

AFP is elevated in hepatocellular carcinoma and yolk-sac (endodermal sinus) tumors.

Question 4

Signet-ring cells filled with mucin pushing the nucleus to the periphery are characteristic of which cancer?

Accepted Answer

Diffuse-type gastric adenocarcinoma

Answer

Signet-ring cells are typical of diffuse (linitis plastica) gastric carcinoma.

Question 5

Caseating granulomas with central 'cheese-like' necrosis are most characteristic of?

Accepted Answer

Tuberculosis

Answer

Caseous (cheese-like) necrosis within granulomas is the hallmark of tuberculosis.

American Board of Pathology (ABPath) Practice Test