ABPath Hematopathology 3

Question 1

t(15;17) with PML-RARA fusion characterizes which subtype of acute myeloid leukemia?

Accepted Answer

Acute promyelocytic leukemia

Answer

APL is defined by t(15;17)/PML-RARA and responds to ATRA therapy.

Question 2

The t(8;14) translocation involving MYC is the classic cytogenetic finding in:

Accepted Answer

Burkitt lymphoma

Answer

Burkitt lymphoma harbors MYC translocation, most commonly t(8;14).

Question 3

A 'starry-sky' pattern on histology with a near-100% Ki-67 proliferation index suggests:

Accepted Answer

Burkitt lymphoma

Answer

Tingible-body macrophages create the starry-sky look, and Ki-67 approaches 100% in Burkitt lymphoma.

Question 4

Hairy cell leukemia is characteristically positive for which mutation?

Accepted Answer

BRAF V600E

Answer

BRAF V600E is present in essentially all hairy cell leukemia cases.

Question 5

TRAP (tartrate-resistant acid phosphatase) positivity and cytoplasmic projections point to which leukemia?

Accepted Answer

Hairy cell leukemia

Answer

Hairy cell leukemia classically shows TRAP positivity and hairy cytoplasmic projections.

American Board of Pathology (ABPath) Practice Test