ABPath Clinical Pathology 3

Question 1

Which blood group antibody is most commonly associated with severe hemolytic disease of the fetus and newborn?

Accepted Answer

Anti-D

Answer

Anti-D is an IgG antibody that readily crosses the placenta and causes severe HDFN.

Question 2

A positive direct antiglobulin test (DAT) with C3d only and cold agglutinins is most consistent with:

Accepted Answer

Cold agglutinin disease

Answer

Cold agglutinin disease typically shows complement (C3d) coating without IgG on the DAT.

Question 3

Which urine finding best supports a diagnosis of acute tubular necrosis rather than prerenal azotemia?

Accepted Answer

Muddy brown granular casts

Answer

Muddy brown granular casts (renal tubular epithelial casts) are characteristic of acute tubular necrosis.

Question 4

Which cerebrospinal fluid profile is most typical of bacterial meningitis?

Accepted Answer

High neutrophils, low glucose, high protein

Answer

Bacterial meningitis classically shows neutrophilic pleocytosis, hypoglycorrhachia, and elevated protein.

Question 5

Which enzyme elevation is most specific for myocardial injury?

Accepted Answer

Cardiac troponin

Answer

Cardiac troponin I and T are the most sensitive and specific markers of myocardial injury.

American Board of Pathology (ABPath) Practice Test