ABPath Anatomic Pathology 3

Question 1

Which marker is a sensitive indicator of vascular/endothelial differentiation?

Accepted Answer

CD31

Answer

CD31 is a highly specific and sensitive endothelial marker used in vascular tumors.

Question 2

Barrett esophagus is defined histologically by replacement of squamous epithelium with:

Accepted Answer

Intestinal-type columnar epithelium with goblet cells

Answer

Barrett esophagus shows intestinal metaplasia with goblet cells in the distal esophagus.

Question 3

Which tumor characteristically shows a 'starry sky' appearance on low power?

Accepted Answer

Burkitt lymphoma

Answer

Tingible-body macrophages among densely packed cells create the starry sky pattern in Burkitt lymphoma.

Question 4

Councilman (apoptotic) bodies are typically seen in:

Accepted Answer

Viral hepatitis

Answer

Councilman bodies are apoptotic hepatocytes seen in viral hepatitis and yellow fever.

Question 5

Which immunostain is the most widely used marker for gastrointestinal stromal tumors (GIST)?

Accepted Answer

CD117 (c-KIT)

Answer

Most GISTs express CD117 (c-KIT), reflecting activating KIT mutations.

American Board of Pathology (ABPath) Practice Test