ABPath Anatomic Pathology 2

Question 1

Psammoma bodies are most characteristically associated with which thyroid malignancy?

Accepted Answer

Papillary carcinoma

Answer

Psammoma bodies (concentric calcifications) are a classic feature of papillary thyroid carcinoma.

Question 2

Which immunohistochemical stain is most useful to confirm a diagnosis of prostatic adenocarcinoma by highlighting loss of basal cells?

Accepted Answer

p63

Answer

p63 marks basal cells, which are absent in invasive prostatic adenocarcinoma.

Question 3

Reed-Sternberg cells are the hallmark of which disease?

Accepted Answer

Classic Hodgkin lymphoma

Answer

Binucleate Reed-Sternberg cells define classic Hodgkin lymphoma.

Question 4

A frozen section is primarily used intraoperatively to:

Accepted Answer

Assess margins and guide surgical decisions

Answer

Frozen sections give rapid guidance on margins and diagnosis during surgery.

Question 5

Which stain is used to identify amyloid deposits, showing apple-green birefringence under polarized light?

Accepted Answer

Congo red

Answer

Congo red stains amyloid and produces apple-green birefringence under polarized light.

American Board of Pathology (ABPath) Practice Test