ABO Ocular Oncology 1

Question 1

What is the most common primary intraocular malignancy in adults?

Accepted Answer

Uveal melanoma

Answer

Uveal melanoma is the most common primary intraocular malignancy in adults, arising from melanocytes in the uveal tract (iris, ciliary body, choroid).

Question 2

Which genetic mutation is most commonly associated with uveal melanoma?

Accepted Answer

GNAQ/GNA11

Answer

GNAQ and GNA11 mutations are found in approximately 80-90% of uveal melanomas, constitutively activating the MAPK signaling pathway.

Question 3

What is the most common site of distant metastasis from uveal melanoma?

Accepted Answer

Liver

Answer

The liver is the predominant site of metastasis in uveal melanoma, with over 90% of patients with metastatic disease having hepatic involvement due to hematogenous spread.

Question 4

Retinoblastoma results from biallelic inactivation of which tumor suppressor gene?

Accepted Answer

RB1

Answer

Retinoblastoma results from biallelic inactivation of the RB1 tumor suppressor gene, illustrating Knudson's classic 'two-hit' model of carcinogenesis.

Question 5

Which of the following is the most common benign intraocular tumor in adults?

Accepted Answer

Choroidal nevus

Answer

Choroidal nevi are the most common benign intraocular tumors, found in approximately 6-7% of the adult Caucasian population, analogous to cutaneous nevi.

ABO - American Board of Ophthalmology Practice Test

ABO - American Board of Ophthalmology Practice Test

ABO Ocular Oncology 1