ABO Ocular Oncology 3

Question 1

What is the first-line treatment approach for bilateral retinoblastoma in modern practice?

Accepted Answer

Systemic chemoreduction followed by focal consolidation

Answer

Modern treatment for bilateral retinoblastoma uses systemic chemoreduction (carboplatin, vincristine, etoposide) followed by focal consolidation (laser, cryotherapy) to achieve globe salvage while avoiding radiation-related secondary malignancies.

Question 2

The DecisionDx-UM gene expression profiling (GEP) test classifies uveal melanoma into which prognostic classes?

Accepted Answer

Class 1A, Class 1B, and Class 2

Answer

The DecisionDx-UM GEP test classifies uveal melanoma into Class 1A (lowest metastatic risk), Class 1B (low-to-intermediate risk), and Class 2 (highest metastatic risk, ~72% 5-year metastasis rate).

Question 3

Sebaceous gland carcinoma of the eyelid is associated with which hereditary syndrome?

Accepted Answer

Muir-Torre syndrome

Answer

Muir-Torre syndrome, caused by germline mutations in DNA mismatch repair genes (MLH1, MSH2), is associated with sebaceous neoplasms of the eyelid and concurrent or subsequent internal visceral malignancies.

Question 4

What is the most common form of intraocular malignancy overall, including secondary tumors?

Accepted Answer

Choroidal metastases

Answer

Choroidal metastases are the most common intraocular malignancy overall, with breast and lung cancer being the most frequent primary sources, reflecting hematogenous spread to the highly vascular choroid.

Question 5

Which ocular tumor is the most common primary intraocular malignancy in children?

Accepted Answer

Retinoblastoma

Answer

Retinoblastoma is the most common primary intraocular malignancy in children, occurring in approximately 1 in 15,000-20,000 live births and arising from primitive retinal precursor cells.

ABO - American Board of Ophthalmology Practice Test

ABO - American Board of Ophthalmology Practice Test

ABO Ocular Oncology 3