ABO Ocular Oncology 2

Question 1

Which chromosomal abnormality in uveal melanoma is most strongly associated with metastatic risk?

Accepted Answer

Monosomy 3

Answer

Monosomy 3 (loss of one copy of chromosome 3) is the single most significant prognostic cytogenetic marker in uveal melanoma, strongly associated with high metastatic risk.

Question 2

Primary intraocular lymphoma (PIOL) most commonly involves which ocular structures?

Accepted Answer

Vitreous and subretinal space

Answer

PIOL is typically a diffuse large B-cell lymphoma that most commonly involves the vitreous and subretinal space, often associated with CNS lymphoma.

Question 3

What is the hallmark CT finding of retinoblastoma in children?

Accepted Answer

Calcification within the intraocular mass

Answer

Calcification within the intraocular tumor is the hallmark CT finding of retinoblastoma, present in approximately 90-95% of cases and helpful in distinguishing it from other leukocoric conditions.

Question 4

Conjunctival melanoma most frequently arises from which precursor lesion?

Accepted Answer

Primary acquired melanosis (PAM) with atypia

Answer

Conjunctival melanoma most commonly (75%) arises from primary acquired melanosis with atypia, which carries a significant risk of malignant transformation proportional to the degree of cytologic atypia.

Question 5

What is the most common orbital malignancy in adults?

Accepted Answer

Lymphoma

Answer

Lymphoma is the most common orbital malignancy in adults, typically presenting as a painless salmon-colored subconjunctival or orbital mass in older patients.

ABO - American Board of Ophthalmology Practice Test

ABO - American Board of Ophthalmology Practice Test

ABO Ocular Oncology 2