Pharm.D. Doctor of Pharmacy Doctor of Pharmacy General 5

Question 1

A Type 2 diabetic patient with eGFR of 25 mL/min/1.73m² should avoid which antidiabetic medication?

Accepted Answer

Metformin

Answer

Metformin is contraindicated when eGFR falls below 30 mL/min/1.73m² due to risk of lactic acidosis from drug accumulation.

Question 2

Which immunosuppressant requires monitoring of blood pressure and serum creatinine due to nephrotoxicity?

Accepted Answer

Cyclosporine

Answer

Cyclosporine causes vasoconstriction of renal afferent arterioles leading to nephrotoxicity and hypertension.

Question 3

What is the pharmacodynamic basis for combining a beta-lactam with an aminoglycoside for serious infections?

Accepted Answer

Synergistic bactericidal activity through dual mechanisms

Answer

Beta-lactams weaken the cell wall, enhancing aminoglycoside penetration, resulting in synergistic killing, especially against Pseudomonas and enterococci.

Question 4

A pharmacist receives a prescription for a Schedule II controlled substance. Which is NOT permitted?

Accepted Answer

Dispensing up to a 90-day supply at once

Answer

Schedule II controlled substances may not be refilled; most states limit supply to 30 days, though some allow longer supplies for specific conditions.

Question 5

Which anticoagulant reversal agent specifically reverses dabigatran?

Accepted Answer

Idarucizumab

Answer

Idarucizumab is a monoclonal antibody fragment that binds dabigatran with high affinity, reversing its anticoagulant effect.

Pharm.D. Doctor of Pharmacy Practice Test

Pharm.D. Doctor of Pharmacy Practice Test

Pharm.D. Doctor of Pharmacy Doctor of Pharmacy General 5