Free Doctor of Pharmacy MCQ Questions and Answers — Questions and Answers
Question 1: You give a 37-year-old woman's neurotic excorations on her arms doxepin to treat. The patient is worried about the medication's adverse effects. Which one of the following is not a doxepin side effect:
- Liver toxicity (Correct answer)
- Somnolence
- Urinary retention
- Xerostomia
Correct answer: Liver toxicity
Doxepin, a tricyclic antidepressant, is well-known for side effects such as somnolence, urinary retention, and xerostomia due to its anticholinergic and antihistaminic properties. While all medications carry some risk of liver impact, significant liver toxicity is not a primary or common adverse effect specifically associated with doxepin.
Question 2: Which condition from the list below exemplifies a type III hypersensitivity reaction?
- Allergic rhinitis
- Lupus (Correct answer)
- Graves disease
- Hashiomoto’s thyroiditis
Correct answer: Lupus
Systemic Lupus Erythematosus (Lupus) is a classic example of a Type III hypersensitivity reaction. In lupus, immune complexes (antigen-antibody complexes) form and deposit in various tissues, such as the kidneys, joints, and skin, leading to inflammation and subsequent tissue damage.
Question 3: Which of the following is a valproic acid side effect?
- Euphoria
- Weight loss
- Pancreatitis (Correct answer)
- Kidney stones
Correct answer: Pancreatitis
Valproic acid is an antiepileptic drug associated with several significant side effects, including gastrointestinal upset, tremor, and weight gain. A serious but less common adverse effect of valproic acid therapy is pancreatitis, which can be severe and potentially life-threatening.
Question 4: Chemotherapy is being given to a 55-year-old woman with metastatic cancer. Due to extreme nausea and vomiting, she makes a threat to cease the treatment. Prochlorperazine will be used by the oncologist to lessen the nausea and vomiting brought on by chemotherapy drugs. What is the prochlorperazine's mode of action?
- Cannabinoids related
- Blockage of prostaglandins
- Serotonin 5-HT3 antagonist
- Blocking dopamine receptors (Correct answer)
Correct answer: Blocking dopamine receptors
Prochlorperazine is a phenothiazine antipsychotic commonly used as an antiemetic. Its antiemetic action primarily stems from its ability to block dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) in the brain, thereby reducing signals that induce nausea and vomiting.
Question 5: A 27-year-old woman is receiving chemotherapy for ovarian cancer. She later gets renal failure. Which substance on the list below is most likely to blame for this?
- Cisplatin (Correct answer)
- Vinblastine
- Bleomycin
- Cyclophosphamide
Correct answer: Cisplatin
Cisplatin is a platinum-based chemotherapy drug highly effective against various cancers, including ovarian cancer. However, a major dose-limiting toxicity of cisplatin is nephrotoxicity (renal failure), which can be severe and requires careful monitoring and hydration strategies to mitigate.
Question 6: A 43-year-old male patient of yours is having trouble voiding after having an elective inguinal hernia repaired. The volume of his post-void residue was 280 cc. Which of the following drugs is the best course of treatment for this patient?
- Finasteride
- Bethanechol (Correct answer)
- Oxybutynin
- Phenylephrine
Correct answer: Bethanechol
The patient is experiencing urinary retention post-surgery, indicated by the high post-void residual volume. Bethanechol is a muscarinic agonist that directly stimulates the detrusor muscle of the bladder, promoting bladder contraction and facilitating urination, making it an appropriate treatment for this condition.
Question 7: Which of the subsequent NSAIDs is a derivative of enolic acid?
- Oxaprozin
- Ibuprofen
- Piroxicam (Correct answer)
- Naproxen
Correct answer: Piroxicam
NSAIDs are classified into different chemical groups based on their structure. Piroxicam is an enolic acid derivative, belonging to the oxicam class of NSAIDs. Other options like ibuprofen and naproxen are propionic acid derivatives.
