Pharm.D. Doctor of Pharmacy Pharmaceutical Chemistry and Drug Design 2

Question 1

Which property is described by the octanol-water partition coefficient (logP)?

Accepted Answer

Relative lipophilicity of a compound

Answer

LogP measures the relative lipophilicity of a compound by comparing its distribution between octanol (lipid-like) and water phases.

Question 2

Which chemical modification increases water solubility of a poorly soluble drug during pharmaceutical formulation?

Accepted Answer

Salt formation or adding ionizable groups

Answer

Salt formation (e.g., converting a weak acid to its sodium salt) or adding ionizable groups significantly increases the aqueous solubility of poorly water-soluble drugs.

Question 3

In the Biopharmaceutics Classification System (BCS), a Class I drug is defined as:

Accepted Answer

High solubility, high permeability

Answer

BCS Class I drugs have both high solubility and high permeability, making them the easiest to develop for oral delivery and candidates for biowaiver applications.

Question 4

Which type of drug-receptor interaction is most easily reversed?

Accepted Answer

Ionic/electrostatic interaction

Answer

Ionic (electrostatic) interactions are reversible and weaker than covalent bonds, making them the most easily disrupted type of drug-receptor interaction.

Question 5

Which concept explains why adding a methyl group to a drug can sometimes significantly alter its receptor selectivity?

Accepted Answer

Steric effects and the 'methyl magic' phenomenon in medicinal chemistry

Answer

In medicinal chemistry, 'methyl magic' refers to the phenomenon where adding a methyl group creates steric interactions that dramatically alter receptor binding selectivity or potency.

Pharm.D. Doctor of Pharmacy Practice Test

Pharm.D. Doctor of Pharmacy Practice Test

Pharm.D. Doctor of Pharmacy Pharmaceutical Chemistry and Drug Design 2