Neuropathy Inflammatory and Immune-Mediated Neuropathy 1

Question 1

What is the most common acute inflammatory demyelinating polyneuropathy?

Accepted Answer

Guillain-Barré Syndrome (GBS)

Answer

GBS is the most common acute inflammatory demyelinating polyneuropathy, typically presenting with rapidly ascending limb weakness following an infection.

Question 2

What duration of symptoms distinguishes CIDP from Guillain-Barré Syndrome?

Accepted Answer

Symptoms lasting more than 8 weeks

Answer

CIDP is defined by a progressive or relapsing course lasting more than 8 weeks, which differentiates it from the acute monophasic course of GBS.

Question 3

Which treatment is considered first-line for Guillain-Barré Syndrome?

Accepted Answer

Intravenous immunoglobulin (IVIG) or plasmapheresis

Answer

IVIG and plasmapheresis are equally effective first-line treatments for GBS, both accelerating recovery by modulating or removing pathogenic immune factors.

Question 4

What is the classic cerebrospinal fluid (CSF) finding in Guillain-Barré Syndrome?

Accepted Answer

Elevated protein with normal white blood cell count (albuminocytologic dissociation)

Answer

Albuminocytologic dissociation — elevated CSF protein without a corresponding increase in white blood cells — is the hallmark CSF finding in GBS.

Question 5

Which antibody is strongly associated with Multifocal Motor Neuropathy (MMN)?

Accepted Answer

Anti-GM1 IgM antibodies

Answer

Anti-GM1 IgM antibodies are found in approximately 50% of MMN patients and help distinguish MMN from ALS and other motor neuron diseases.

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Neuropathy Inflammatory and Immune-Mediated Neuropathy 1