Neuropathy Neuropathy Medications and Drug-Induced Neuropathy

Question 1

Which antiretroviral drug class is most commonly associated with antiretroviral toxic neuropathy (ATN)?

Accepted Answer

Nucleoside reverse transcriptase inhibitors (NRTIs)

Answer

Protease inhibitors

Answer

Integrase inhibitors

Answer

CCR5 antagonists

Question 2

Bortezomib (Velcade), used in multiple myeloma, causes neuropathy through which primary mechanism?

Accepted Answer

Disruption of axonal transport and mitochondrial dysfunction

Answer

Autoimmune demyelination

Answer

Direct myelin protein degradation

Answer

Inflammatory cytokine release

Question 3

Pyridoxine (vitamin B6) toxicity from mega-dose supplementation causes which type of neuropathy?

Accepted Answer

Pure sensory ganglionopathy with sensory ataxia

Answer

Motor neuropathy with foot drop

Answer

Autonomic neuropathy with orthostatic hypotension

Answer

Cranial neuropathy affecting vision

Question 4

Which antibiotic is associated with peripheral neuropathy, particularly with prolonged use or in patients with renal failure?

Accepted Answer

Metronidazole

Answer

Amoxicillin

Answer

Doxycycline

Answer

Azithromycin

Question 5

Colchicine toxicity causing neuromuscular complications presents as which pattern?

Accepted Answer

Neuromyopathy with proximal weakness and elevated CK

Answer

Pure sensory neuropathy with paresthesias

Answer

Acute demyelinating polyneuropathy

Answer

Mononeuritis multiplex

Question 6

Which lipid-lowering medication class is associated with a small but recognized risk of peripheral neuropathy?

Accepted Answer

Statins

Answer

Fibrates

Answer

Bile acid sequestrants

Answer

Niacin