Neuropathy Neuropathy Causes and Risk Factors 2

Question 1

Which chemotherapy drug class is most commonly associated with chemotherapy-induced peripheral neuropathy (CIPN)?

Accepted Answer

Taxanes and platinum compounds

Answer

Taxanes (e.g., paclitaxel) and platinum compounds (e.g., oxaliplatin) are the most neurotoxic chemotherapy classes.

Question 2

Hypothyroidism can cause neuropathy through which primary mechanism?

Accepted Answer

Deposition of mucopolysaccharides compressing nerves

Answer

Hypothyroidism causes mucopolysaccharide deposits in tissues that compress peripheral nerves, especially causing carpal tunnel syndrome.

Question 3

Which autoimmune condition commonly causes a painful sensory neuropathy due to dorsal root ganglion inflammation?

Accepted Answer

Sjögren's syndrome

Answer

Sjögren's syndrome can cause a ganglionopathy by attacking dorsal root ganglia, producing sensory ataxia and pain.

Question 4

Which occupational exposure is a recognized risk factor for toxic peripheral neuropathy?

Accepted Answer

Lead and heavy metal exposure

Answer

Lead and other heavy metals (arsenic, mercury, thallium) are well-established occupational neurotoxins causing peripheral neuropathy.

Question 5

Which connective tissue disease causes neuropathy via vasculitis affecting the vasa nervorum?

Accepted Answer

Polyarteritis nodosa

Answer

Polyarteritis nodosa causes vasculitis of the small vessels supplying nerves, leading to ischemic neuropathy.

Neuropathy Practice Test