NAVLE Veterinary Pharmacology 2

Question 1

Which opioid analgesic is commonly used in cats but must be used cautiously due to their limited glucuronidation capacity?

Accepted Answer

Buprenorphine

Answer

Buprenorphine is preferred in cats because its partial agonist activity and high mu-receptor affinity make it effective at lower doses, reducing the risk of adverse effects from impaired glucuronidation.

Question 2

A dog is prescribed phenobarbital for seizure control. Which of the following is the most important monitoring parameter for long-term therapy?

Accepted Answer

Serum bile acids and liver enzymes

Answer

Phenobarbital induces hepatic enzymes and can cause hepatotoxicity with long-term use, so serum bile acids and liver enzymes must be monitored regularly.

Question 3

Which drug class is contraindicated in cats due to their deficiency in UDP-glucuronosyltransferase?

Accepted Answer

NSAIDs metabolized via glucuronidation

Answer

Cats lack sufficient UDP-glucuronosyltransferase activity, making drugs like acetaminophen and certain NSAIDs dependent on glucuronidation highly toxic.

Question 4

A horse develops laminitis after prolonged use of which drug class?

Accepted Answer

Corticosteroids

Answer

Prolonged corticosteroid use in horses can lead to laminitis due to alterations in digital blood flow and carbohydrate metabolism.

Question 5

Which antimicrobial is most appropriate for treating Rhodococcus equi pneumonia in foals?

Accepted Answer

Rifampin combined with azithromycin or clarithromycin

Answer

Rifampin combined with a macrolide (azithromycin or clarithromycin) is the standard of care for Rhodococcus equi because the combination achieves good intracellular penetration.

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE Veterinary Pharmacology 2