NAVLE Feline Pharmacology and Toxicology Questions and Answers

Question 1

A 2-year-old indoor cat is presented to the emergency clinic with acute onset of vomiting, lethargy, and anorexia.
The owner recently received a floral arrangement containing lilies.
On physical examination, the cat is dehydrated and has painful kidneys on palpation.
Bloodwork reveals severe azotemia.
Which of the following is the most critical initial treatment for this suspected toxicity?

Accepted Answer

Intravenous fluid diuresis

Answer

N-acetylcysteine administration

Answer

Administration of activated charcoal and a cathartic

Answer

Peritoneal dialysis

Question 2

A cat is accidentally administered a dose of acetaminophen (paracetamol). Which clinical sign is most characteristic of this specific toxicity in felines due to their metabolic differences?

Accepted Answer

Methemoglobinemia and facial edema

Answer

Severe gastrointestinal ulceration

Answer

Acute fulminant hepatic necrosis

Answer

Profound coagulopathy

Question 3

A 12-year-old cat diagnosed with hyperthyroidism is started on oral methimazole. Within the first three weeks of treatment, the owner reports the cat is scratching its face and neck incessantly, causing excoriations. Which of the following is the most appropriate action?

Accepted Answer

Discontinue methimazole and discuss alternative treatments like radioiodine (I-131) therapy.

Answer

Decrease the dose of methimazole by half and recheck in one week.

Answer

Add a glucocorticoid to the treatment regimen to control the pruritus.

Answer

Switch to the transdermal formulation of methimazole.

Question 4

A cat presents with acute onset of severe muscle tremors, hyperthermia, and mydriasis after the owner applied a canine-specific flea and tick spot-on product. Which of the following toxicities is most likely, and what is the primary therapeutic agent used to control the tremors?

Accepted Answer

Permethrin toxicity; Methocarbamol

Answer

Organophosphate toxicity; Atropine

Answer

Ethylene glycol toxicity; Fomepizole

Answer

Ivermectin toxicity; Intralipid emulsion

Question 5

Amlodipine is the first-line treatment for systemic hypertension in cats. What is its primary mechanism of action?

Accepted Answer

Calcium channel blockade

Answer

Angiotensin-converting enzyme (ACE) inhibition

Answer

Beta-adrenergic receptor blockade

Answer

Alpha-adrenergic receptor antagonism

Question 6

Which of the following best describes the primary mechanism by which non-steroidal anti-inflammatory drugs (NSAIDs) can induce acute kidney injury in a cat that is dehydrated or hypotensive?

Accepted Answer

Inhibition of prostaglandin-mediated renal vasodilation

Answer

Direct nephron apoptosis via oxidative damage

Answer

Formation of obstructive crystals within the renal tubules

Answer

Immune-mediated glomerulonephritis