NAVLE Feline Pharmacology and Toxicology 4

Question 1

Which antiparasitic drug has a narrow safety margin in cats and can cause mydriasis, ataxia, tremors, and death if overdosed, particularly in debilitated individuals?

Accepted Answer

Ivermectin

Answer

Ivermectin toxicity in cats causes CNS signs by enhancing GABA-mediated inhibition; cats lack MDR1 mutation but are still sensitive to overdose.

Question 2

Gabapentin is increasingly used in cats for anxiety and pain. Which pharmacokinetic property is clinically important in feline dosing?

Accepted Answer

It is renally excreted unchanged and dose must be reduced with renal insufficiency

Answer

Gabapentin is eliminated renally with minimal hepatic metabolism, so dose intervals must be extended in cats with chronic kidney disease.

Question 3

A cat presents comatose after ingesting ethylene glycol. Which diagnostic finding would confirm ethylene glycol toxicity?

Accepted Answer

Calcium oxalate monohydrate crystalluria

Answer

Ethylene glycol is metabolized to oxalic acid, which combines with calcium to form calcium oxalate monohydrate crystals visible in urine sediment.

Question 4

Which statement about the use of doxycycline in cats is most accurate?

Accepted Answer

Liquid or food must accompany doxycycline administration to prevent esophageal stricture

Answer

Doxycycline pills lodged in the feline esophagus cause chemical strictures; always follow tablets with food or water, or use liquid formulations.

Question 5

A cat develops bradycardia and hypotension following topical application of an ophthalmic timolol solution. What is the mechanism of this adverse effect?

Accepted Answer

Systemic absorption of the beta-blocker through the nasolacrimal duct

Answer

Timolol is absorbed systemically via the nasolacrimal duct in cats, exerting beta-1 blockade effects on heart rate and blood pressure.

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE Feline Pharmacology and Toxicology 4