NAVLE Feline Pharmacology and Toxicology 3

Question 1

Acetaminophen (paracetamol) toxicity in cats primarily causes which two clinical findings?

Accepted Answer

Methemoglobinemia and hepatic necrosis

Answer

Cats lack sufficient glucuronyl transferase to conjugate acetaminophen, leading to methemoglobinemia (muddy mucous membranes) and hepatic necrosis.

Question 2

A 4 kg cat requires ketamine for induction. Which statement about ketamine in cats is most accurate?

Accepted Answer

It must be combined with a benzodiazepine or alpha-2 agonist to prevent seizure-like muscle rigidity

Answer

Ketamine alone causes muscle hypertonicity and vocalization; co-administration of diazepam or medetomidine produces smooth induction.

Question 3

Which NSAID is FDA-approved for long-term pain management in cats in the United States?

Accepted Answer

Robenacoxib

Answer

Robenacoxib (Onsior) is the only NSAID approved for longer-term use in cats in the US; meloxicam is approved for single-dose injection only.

Question 4

Xylitol ingestion in cats compared to dogs is best described as:

Accepted Answer

Less understood; cats appear more resistant to xylitol-induced hypoglycemia than dogs

Answer

Current evidence suggests cats are less susceptible to xylitol-induced hypoglycemia than dogs, though caution is still warranted and monitoring is recommended.

Question 5

A cat is receiving cyclosporine for feline atopic dermatitis. Which concurrent drug would most significantly increase cyclosporine blood levels?

Accepted Answer

Ketoconazole

Answer

Ketoconazole inhibits CYP3A4 (the primary enzyme metabolizing cyclosporine), substantially increasing cyclosporine plasma concentrations.

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE Feline Pharmacology and Toxicology 3