NAVLE Feline Pharmacology and Toxicology 2

Question 1

A cat presents with sedation, hypersalivation, and ataxia after grooming itself following topical permethrin application intended for dogs. What is the most appropriate treatment?

Accepted Answer

Bathe with mild dish soap and provide supportive care including muscle relaxants

Answer

Permethrin toxicity in cats causes neurological signs; bathing removes the toxin and methocarbamol or diazepam controls tremors.

Question 2

Which fluoroquinolone antibiotic is most associated with acute retinal degeneration and blindness in cats when used at high doses?

Accepted Answer

Enrofloxacin

Answer

Enrofloxacin at doses above 5 mg/kg/day causes retinal degeneration in cats due to accumulation in the retinal pigment epithelium.

Question 3

A cat is prescribed methimazole for hyperthyroidism. Which adverse effect is most commonly reported in the first 1–3 months of therapy?

Accepted Answer

Facial pruritus and excoriation

Answer

Facial pruritus, excoriation, and self-induced facial lesions are the most common early adverse effects of methimazole in cats.

Question 4

Lily (Lilium spp.) ingestion in cats primarily targets which organ system?

Accepted Answer

Renal system

Answer

True lily ingestion in cats causes acute renal failure due to nephrotoxic steroidal glycosides; even small amounts can be fatal.

Question 5

When using buprenorphine in cats, which route of administration achieves good bioavailability due to the cat's naturally alkaline oral pH?

Accepted Answer

Transmucosal (sublingual/buccal)

Answer

The alkaline oral pH of cats promotes ionization of buprenorphine at mucosal surfaces, giving transmucosal administration ~100% bioavailability.

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE - North American Veterinary Licensing Examination Practice Test

NAVLE Feline Pharmacology and Toxicology 2