HRT HRT Delivery Methods & Administration 3

Question 1

Which absorption factor most significantly affects the bioavailability of transdermal testosterone cream in women?

Accepted Answer

Application site skin thickness

Answer

Thinner skin at the application site (e.g., inner wrist vs. thicker abdominal skin) results in higher transdermal hormone absorption.

Question 2

Sublingual estradiol troches are typically held under the tongue for how long to optimize absorption?

Accepted Answer

5–10 minutes until dissolved

Answer

Sublingual troches must dissolve fully under the tongue over 5–10 minutes to allow absorption through the sublingual mucosa into the bloodstream.

Question 3

What is the MAIN reason compounded HRT preparations are not FDA-approved?

Accepted Answer

They are not subjected to the same standardized clinical trial and manufacturing approval process

Answer

Compounded preparations are patient-specific and not required to undergo the FDA's rigorous new drug application (NDA) process for safety, efficacy, and manufacturing standards.

Question 4

Vaginal estrogen creams are applied locally to treat which condition while minimizing systemic estrogen exposure?

Accepted Answer

Genitourinary syndrome of menopause (GSM)

Answer

Low-dose vaginal estrogen primarily treats GSM symptoms such as vaginal dryness, dyspareunia, and urinary urgency with minimal systemic absorption.

Question 5

A twice-weekly estradiol patch is changed on Monday. The next change should occur on which day?

Accepted Answer

Thursday

Answer

A twice-weekly patch worn Monday requires replacement on Thursday to maintain the approximately 3–4 day change schedule.

HRT - Hormone Replacement Therapy Certification Practice Test

HRT - Hormone Replacement Therapy Certification Practice Test

HRT HRT Delivery Methods & Administration 3