HRT HRT Contraindications & Risk Factors

Question 1

Which condition is an ABSOLUTE contraindication to systemic estrogen-containing HRT?

Accepted Answer

Active or history of estrogen receptor-positive breast cancer

Answer

Well-controlled hypertension

Answer

Type 2 diabetes

Answer

Mild osteoporosis

Question 2

A patient with a personal history of deep vein thrombosis (DVT) who requires HRT should preferably use which route to minimize thrombotic risk?

Accepted Answer

Transdermal estrogen

Answer

Oral conjugated estrogen

Answer

IV estrogen

Answer

High-dose oral estrogen

Question 3

Undiagnosed abnormal vaginal bleeding is a contraindication to HRT initiation because it may indicate which serious underlying condition?

Accepted Answer

Endometrial cancer or hyperplasia

Answer

Benign fibroids only

Answer

Ovarian cysts

Answer

Cervical polyps only

Question 4

Active liver disease is a relative or absolute contraindication to HRT primarily because the liver is responsible for what?

Accepted Answer

Metabolizing and clearing exogenous hormones

Answer

Producing ovarian hormones

Answer

Absorbing hormones from the GI tract

Answer

Regulating FSH and LH secretion

Question 5

Which inherited thrombophilia markedly increases VTE risk with oral HRT and may prompt use of transdermal route instead?

Accepted Answer

Factor V Leiden mutation

Answer

MTHFR heterozygous variant alone

Answer

G6PD deficiency

Answer

Hemophilia A

Question 6

Migraine with aura is considered a relative contraindication to combined oral contraceptives and is relevant to HRT because it indicates increased risk of which event?

Accepted Answer

Ischemic stroke

Answer

Hemorrhagic stroke

Answer

Pulmonary embolism

Answer

Myocardial infarction only