HRT HRT for Male Patients (Testosterone Therapy)

Question 1

What is the diagnostic criterion for primary hypogonadism in men using morning serum total testosterone?

Accepted Answer

Total testosterone <300 ng/dL on two separate morning measurements

Answer

Total testosterone <500 ng/dL on one reading

Answer

FSH >10 mIU/mL alone

Answer

Free testosterone <1% of total

Question 2

Why should testosterone levels be measured in the morning for male HRT evaluation?

Accepted Answer

Testosterone follows a diurnal rhythm, peaking in the morning and declining throughout the day

Answer

Labs only process samples in the morning

Answer

Afternoon samples require a different reference range

Answer

Morning samples avoid dietary interference

Question 3

Which laboratory value must be checked before initiating testosterone therapy in men to rule out secondary causes of hypogonadism?

Accepted Answer

LH and FSH

Answer

Vitamin D only

Answer

Thyroid TSH only

Answer

A1C

Question 4

Testosterone therapy in men suppresses which endogenous process, potentially reducing fertility?

Accepted Answer

Spermatogenesis via hypothalamic-pituitary-gonadal axis suppression

Answer

Hepatic albumin synthesis

Answer

Adrenal cortisol production

Answer

Thyroid hormone conversion

Question 5

For men on testosterone therapy who wish to preserve fertility, which adjunctive therapy is used to maintain spermatogenesis?

Accepted Answer

Human chorionic gonadotropin (hCG)

Answer

Clomiphene citrate only

Answer

Aromatase inhibitors only

Answer

GnRH antagonist

Question 6

Polycythemia (elevated hematocrit) is a known complication of testosterone therapy. At what hematocrit level should TRT be paused?

Accepted Answer

>54%

Answer

>45%

Answer

>50%

Answer

>60%