HRT HRT Delivery Methods & Administration 3

Question 1

Which absorption factor most significantly affects the bioavailability of transdermal testosterone cream in women?

Accepted Answer

Application site skin thickness

Answer

Time of day applied

Answer

Ambient temperature only

Answer

Patient's blood type

Question 2

Sublingual estradiol troches are typically held under the tongue for how long to optimize absorption?

Accepted Answer

5–10 minutes until dissolved

Answer

30 seconds then swallowed

Answer

1 hour

Answer

Chewed and swallowed immediately

Question 3

What is the MAIN reason compounded HRT preparations are not FDA-approved?

Accepted Answer

They are not subjected to the same standardized clinical trial and manufacturing approval process

Answer

They contain illegal substances

Answer

They are made outside the US

Answer

They are only for veterinary use

Question 4

Vaginal estrogen creams are applied locally to treat which condition while minimizing systemic estrogen exposure?

Accepted Answer

Genitourinary syndrome of menopause (GSM)

Answer

Hot flashes

Answer

Osteoporosis

Answer

Mood disturbances

Question 5

A twice-weekly estradiol patch is changed on Monday. The next change should occur on which day?

Accepted Answer

Thursday

Answer

Wednesday

Answer

Sunday

Answer

Friday

Question 6

Which HRT delivery method is MOST suitable for a patient with a documented adhesive allergy to patch backing?

Accepted Answer

Topical gel or cream

Answer

Transdermal patch

Answer

Oral tablet with a coating agent

Answer

Intradermal injection