HRT HRT Delivery Methods & Administration 1 — Questions and Answers
Question 1: Which HRT delivery method provides the most consistent serum hormone levels by bypassing first-pass hepatic metabolism?
- Transdermal patch (Correct answer)
- Oral tablet
- Vaginal cream
- Sublingual drop
Correct answer: Transdermal patch
Transdermal patches deliver hormones directly into the bloodstream, avoiding first-pass liver metabolism and producing more stable serum levels.
Question 2: What is the primary advantage of subcutaneous pellet implants over other HRT delivery methods?
- Sustained hormone release over 3–6 months (Correct answer)
- Immediate dose adjustment flexibility
- Lowest cost option
- Easiest self-administration
Correct answer: Sustained hormone release over 3–6 months
Subcutaneous pellets slowly dissolve under the skin, releasing hormones consistently for 3–6 months without daily administration.
Question 3: When applying a transdermal estrogen gel, which site is MOST appropriate?
- Upper arm or inner thigh (Correct answer)
- Scalp
- Face
- Breast tissue
Correct answer: Upper arm or inner thigh
Transdermal estrogen gel should be applied to clean, dry skin on the upper arm or inner thigh, avoiding mucous membranes and breast tissue.
Question 4: Which route of progesterone administration is associated with the lowest risk of hepatic side effects?
- Vaginal suppository (Correct answer)
- Oral tablet
- Intramuscular injection
- Sublingual tablet
Correct answer: Vaginal suppository
Vaginal progesterone bypasses hepatic first-pass metabolism, resulting in high uterine bioavailability with minimal systemic liver exposure.
Question 5: Intramuscular testosterone cypionate injections are typically administered at what interval for male HRT?
- Every 1–2 weeks (Correct answer)
- Daily
- Monthly
- Every 6 months
Correct answer: Every 1–2 weeks
Testosterone cypionate has a half-life that makes every 1–2 week IM injections the standard dosing interval for steady hormone levels.
Question 6: Which HRT formulation is considered a bioidentical hormone because its molecular structure is identical to endogenous human estradiol?
- 17β-estradiol (Correct answer)
- Conjugated equine estrogen
- Ethinyl estradiol
- Mestranol
Correct answer: 17β-estradiol
17β-estradiol has an identical molecular structure to the estradiol naturally produced by human ovaries, classifying it as bioidentical.
HRT HRT Delivery Methods & Administration 1
Which HRT delivery method provides the most consistent serum hormone levels by bypassing first-pass hepatic metabolism?