HRT HRT Delivery Methods & Administration 2

Question 1

A patient on oral estrogen therapy develops elevated triglycerides. What delivery method change should be considered?

Accepted Answer

Switch to transdermal estrogen

Answer

Transdermal estrogen avoids hepatic first-pass metabolism, which is responsible for the triglyceride elevation seen with oral estrogen.

Question 2

What is the recommended rotation practice for transdermal estrogen patches to minimize skin irritation?

Accepted Answer

Rotate sites with each patch change

Answer

Rotating the application site with each patch change prevents skin irritation, contact sensitization, and poor adhesion from repeated use at the same spot.

Question 3

Testosterone pellet insertion is performed in which anatomical location?

Accepted Answer

Upper buttock or hip subcutaneous tissue

Answer

Testosterone pellets are inserted into the subcutaneous fat of the upper buttock or hip via a small trocar incision under local anesthesia.

Question 4

Which vehicle base is used in most compounded transdermal hormone creams to enhance skin penetration?

Accepted Answer

PLO (Pluronic Lecithin Organogel)

Answer

PLO gel is the most common transdermal base in compounded HRT because its lecithin component enhances percutaneous absorption through the skin.

Question 5

For a patient who cannot tolerate oral progesterone due to sedation, which alternative route minimizes CNS side effects?

Accepted Answer

Vaginal progesterone

Answer

Vaginal progesterone achieves high uterine levels with lower systemic absorption, significantly reducing the sedative CNS effects associated with oral use.

HRT - Hormone Replacement Therapy Certification Practice Test

HRT - Hormone Replacement Therapy Certification Practice Test

HRT HRT Delivery Methods & Administration 2