Endocrine Weight Loss Endocrine Disorders 2

Question 1

Which adrenal disorder causes central obesity, purple striae, and hypertension due to excess cortisol?

Accepted Answer

Cushing's syndrome

Answer

Cushing's syndrome results from excess cortisol, causing central (truncal) obesity, purple striae, hypertension, and buffalo hump.

Question 2

A patient with type 2 diabetes and obesity has an HbA1c of 8.5%. Which GLP-1 receptor agonist is FDA-approved for both glycemic control and weight loss?

Accepted Answer

Semaglutide

Answer

Semaglutide (Ozempic/Wegovy) is a GLP-1 receptor agonist FDA-approved for both type 2 diabetes management and chronic weight management.

Question 3

Which hormone produced by adipose tissue signals the hypothalamus to suppress appetite and increase energy expenditure?

Accepted Answer

Leptin

Answer

Leptin is produced by adipocytes and acts on hypothalamic receptors to suppress hunger and promote energy expenditure.

Question 4

Polycystic ovary syndrome (PCOS) contributes to weight gain primarily through which mechanism?

Accepted Answer

Insulin resistance and hyperinsulinemia

Answer

PCOS is strongly associated with insulin resistance and hyperinsulinemia, which drives androgen excess and promotes fat storage.

Question 5

Which finding on labs would most strongly suggest primary hypothyroidism as a cause of weight gain?

Accepted Answer

High TSH with low free T4

Answer

Primary hypothyroidism is characterized by elevated TSH (pituitary compensation) and low free T4 due to underactive thyroid gland output.

Endocrine Weight Loss Practice Test

Endocrine Weight Loss Practice Test

Endocrine Weight Loss Endocrine Disorders 2