Cord Blood Banking 3

Question 1

Which factor most directly determines whether a cord blood unit can be used for an adult patient?

Accepted Answer

Total nucleated cell dose per kilogram of recipient body weight

Answer

Adequate TNC dose per kilogram of recipient weight is the primary predictor of engraftment success; adults often need larger units or double-unit transplants.

Question 2

A private cord blood bank closes unexpectedly. Under what protection do stored units typically transfer to another facility?

Accepted Answer

Contractual obligations and state escrow laws

Answer

Most private banking contracts include transfer provisions, and some states require escrow accounts to fund sample transfer if a bank ceases operations.

Question 3

What is 'HLA typing' in the context of cord blood banking?

Accepted Answer

Genetic matching of human leukocyte antigens between donor and recipient

Answer

HLA typing identifies human leukocyte antigen proteins on cells, allowing banks to match donor units to recipients for compatible transplants.

Question 4

Which cord blood bank accreditation body is recognized specifically in the United States and focuses on hematopoietic progenitor cells?

Accepted Answer

FACT (Foundation for the Accreditation of Cellular Therapy)

Answer

FACT accreditation is the gold standard for hematopoietic progenitor cell programs in the US, covering standards for collection, processing, storage, and administration.

Question 5

Why do most cord blood banks recommend collecting at least 60–80 mL of cord blood?

Accepted Answer

To ensure enough cells for processing, testing, and a viable transplant unit

Answer

A minimum collection volume of 60–80 mL is needed to yield a sufficient number of stem cells after processing losses and infectious disease testing.

Cord Blood Practice Test

Cord Blood Practice Test

Cord Blood Banking 3