Cord Blood Cord Blood Transplantation

Question 1

What conditioning regimen is administered to patients before a cord blood transplant and why?

Accepted Answer

High-dose chemotherapy and/or radiation to destroy diseased marrow and make space for donor cells

Answer

Antibiotics to prevent infection only

Answer

Low-dose corticosteroids to reduce inflammation

Answer

Blood transfusions to boost cell counts

Question 2

What is the typical time to neutrophil engraftment following a cord blood transplant compared to bone marrow transplant?

Accepted Answer

Slower at 21–28 days or more

Answer

Faster at 7–10 days

Answer

Similar at 10–14 days

Answer

Immediate within 24 hours

Question 3

What is double cord blood transplantation (dCBT)?

Accepted Answer

Infusing two unrelated cord blood units to increase cell dose for adult recipients

Answer

Using two units of cord blood from the same donor

Answer

Performing two separate transplants one year apart

Answer

Mixing cord blood with bone marrow

Question 4

What does HLA (Human Leukocyte Antigen) matching refer to in cord blood transplantation?

Accepted Answer

Matching immune recognition proteins between donor and recipient to reduce rejection risk

Answer

Matching blood types between donor and recipient

Answer

Matching the volume of cord blood units

Answer

Matching the age of the donor and recipient

Question 5

Which HLA loci are typically evaluated when selecting a cord blood unit for transplant?

Accepted Answer

HLA-A, HLA-B, and HLA-DRB1

Answer

HLA-C and HLA-E only

Answer

HLA-G and HLA-F only

Answer

Only blood group ABO

Question 6

What is primary graft failure in cord blood transplantation?

Accepted Answer

Failure of donor stem cells to engraft and produce blood cells within the expected timeframe

Answer

GVHD occurring within 14 days

Answer

Bacterial infection following transplant

Answer

Relapse of the original disease